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Results for more stringent outcomes can be found in the supplementary figures.
Not surprisingly, methotrexate-treated patients experienced significantly higher progression of joint damage when less stringent outcomes were used, such as DAS28 CRP) remission or LDA, compared with the new ACR/EULAR criteria.
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The association of differentiation to changes in the threshold level represents the most stringent outcome of this model, and is in principle amenable to experimental test, as it will be discussed in the final section.
Only three (4% of 77) met the most stringent outcome that added that a sample-size calculation was given.
The use of anti-asthmatic medications may be considered a more stringent outcome definition, identifying only the most serious cases; in the MCS only children taking daily medications in the last 2 weeks are identified.
Altogether, these findings further highlight the value of targeting stringent remission outcomes, as recommended by ACR-EULAR [ 2].
To do so we chose stringent primary outcome measures for treatment efficacy including pain and total migraine freedom at 2 h [8].
Eight (10% of 77) met the more-stringent composite outcome that added that the euthanasia method was appropriate for species.
Studies that used more stringent definitions of outcomes had lower placebo rates of remission and response.
Regrettably, as our review shows, few of these have been subjected to any stringent evaluation of outcomes.
We observed, however, that several studies did not use the stringent culture-based outcome definitions such as Cure or Failed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com