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We have presented a preliminary report of a less cumbersome and more stringent method for detecting integrated viral DNA in cells [ 5].
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With the decrease in runtime, permutation tests for significance become a feasible option, resulting in increased power compared with stringent methods for multiple hypothesis correction.
Taken together, there is a need for large-scale studies that rely on more stringent methods for examining the psychometric properties of the DAS-A.
Three of these studies used stringent methods for the preprocessing and analysis of data and for FDR control (they used positive and negative controls) (Chauhan et al. 2007; Qutob et al. 2006; Whitehead et al. 2006).
"It's a form of genocide," says Dolene Miller, a member of the National Commission for Demarcation and Titling, which has been fighting for a more stringent method of keeping track of land titles for indigenous and afro-descendent people.
Multiple testing was accounted for by applying the particularly stringent method of Bonferroni Correction.
The p-values of individual nutrients are not small and do not survive the more stringent methods of correction for multiple testing.
The assay strategy with one common probe length and multiple stringencies produced a high success rate (above 90%) with method A for calling genotypes, but dropped below 40% when using the more stringent method D for assigning genotypes (Figure 4A and D, strategy 5).
Overall, due to the very stringent method applied for gene selection, most often we did not find a signature and when it was found the 'false R'-tumor systematically localized between the two groups of R- and S-tumors.
Ideally, stringent methods of validation and reliability testing are required.
Based on the results obtained in the above analyses (comparing response versus status and "more stringent" versus "less stringent" methods), results for onset and durability were only reported for ACR50 and LDAS, as these measures were of comparable stringency and numbers of responders were high enough to enable meaningful interpretation of the results.
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CEO of Professional Science Editing for Scientists @ prosciediting.com