Sentence examples for stringent linkage from inspiring English sources

We compare different conditions such as naïve SNP assignments and stringent linkage disequilibrium (LD) free assignments for transcripts to remove confounders from LD.

A highly stringent linkage analysis method was conducted, using the double pseudo-testcross strategy [ 134], as in other linkage analyses of hop [ 14- 17].

However, the statistical significance between familial longevity and the Alzheimer's disease genetic risk score was lost when a more stringent linkage disequilibrium threshold was imposed to select independent genetic variants.

Among 1,053,393 deaths recorded 1991 20075.4%% could not be linked using stringent probabilistic linkage.

Proteins were clustered using a stringent double-linkage algorithm, in which filtered, reciprocal protein pairs for A, B, and C must all exist for proteins A, B, and C to be clustered.

Utilizing a small number of probes designed as substrate analogs, we were able to expose a limitation in accepted substrate linkages (secondary and tertiary amides) and a flexible catalytic reduction site (C1 vs C3 reduction in diketone thioether substrates), indicating a stringent preference in linkage region with a flexible reduction locale in the active site, respectively.

These standard estimates of constraint and adaptation become more stringent under conditions of genetic linkage.

In addition to this key feature of data linkage, there are stringent site-specific processes such as technical and physical protections of data.

This suggests that there must be other susceptibility genes whose contributions were not big enough to reach the stringent significance threshold value of linkage analysis.

We judged requiring five informative meioses or positive evidence of linkage as unreasonably stringent criteria and only requiring two affected family members in two generations as too lax a criterion for association of a variant with disease.

Thirdly, the 'autogroup' option was used to cluster markers into linkage groups, starting with more stringent parameters and proceeding to less stringent parameters.