Although some authors have argued that this conjunction tests a less stringent hypothesis than the 'conjoint' conjunction (Nichols et al., 2005), we opted for this analysis for the group comparison because a 'global' conjunction is more sensitive than a 'conjoint' conjunction analysis (Friston et al., 2005).
This strongly argues for a stringent, at best hypothesis-driven pre-selection of relevant subgroup representatives, which might enable investigators to reveal corresponding molecular mechanisms in SCZ.
Completed studies with lanicemine now encompass the largest pool of depressed patients (n>120) exposed to an NMDA channel blocker to date, and represent a stringent test of the hypothesis that NMDAR antagonists can deliver antidepressant efficacy independent of psychotomimetic side effects.
A less stringent correction for multiple hypothesis testing is the False Discovery Rate (FDR) [15].
These additional constraints will only make the random null hypothesis more stringent to refute.
With the decrease in runtime, permutation tests for significance become a feasible option, resulting in increased power compared with stringent methods for multiple hypothesis correction.
By correlating the expression patterns of individual proteins with HB scores, we identified seven putative biomarkers of HB that survived stringent control for multiple hypothesis testing.
In addition, word-specific accounts (Gaillard et al. 2006) imply that pure alexia is specific to alphabetical material (words and/or letters), and comparing performance with letters and digits seems to be a stringent test of this hypothesis.
It should be noted that in future studies, larger sample sizes would be more optimal in testing these scales, and further allow for more stringent analyses to test the hypotheses.
As a more stringent test of the LTD hypothesis, we have previously studied Purkinje cell responses to pf stimuli8 (for details of the methodology, see ref.8).
