Sentence examples for stringent factor from inspiring English sources

The failure of vancomycin to increase synthesis of the stringent factor ppGpp while modulating expression of many stringently controlled genes suggests the former, but simultaneous induction of transcription of σB and the σB regulon, and of σE and the σE-dependent gene SCO3202, by all three antibiotics would be indicative of the latter.

Because of the high cost of failure, the reliability performance of power semiconductor devices is becoming a more and more important and stringent factor in many energy conversion applications.

During deprivation of nutrients, uncharged transfer RNAs (tRNAs) bind to the ribosome and activate the stringent factor, RelA, which recognizes stalled ribosomes and catalyzes synthesis of the signal nucleotide, (p ppGpp.

The stringent factor ppGpp is an intracellular signalling molecule that is synthesised in S. coelicolor in response to amino acid limitation, and which co-ordinates an adaptive response to the changing nutritional conditions that includes down-regulation of processes associated with active growth, and up-regulation of systems that may help it survive the nutritional stress [ 21].

The effects on transition-phase expression of ribosomal protein-encoding genes raised the possibility that the changes might be mediated via ppGpp, the stringent factor that controls transcription of rRNA and certain ribosomal protein operons in E. coli and many other bacteria, including streptomycetes [ 6].

Here we chose stringent factors that produce a manageable number of proteins.

Carbon sensing, transport and metabolism; general stress response; stringent response; factors determining intercellular communication, aggregative and social behaviour; nitrogen metabolism; energy status.

The genes whose enhanced expression affected glycogen accumulation were classified into various functional categories including carbon sensing, transport and metabolism, general stress and stringent responses, factors determining intercellular communication, aggregative and social behaviour, nitrogen metabolism and energy status.

Although this could explain how pausing ribosomes are recovered for rescue by tmRNA in the absence of stringent response factors (Hayes and Sauer, 2003; Kamada and Hanaoka, 2005; Sunohara et al., 2004), recent data suggest that cleavage is most likely a result of the combined action of RelE-like endonucleases and exonucleases like RNase II (Garza-Sanchez et al., 2009).

Taken together, whereas the need for tight disease activity control has been amply documented, our findings also stress the notion that more stringent CVD risk factor control is required in at least a clinically relevant proportion of patients with RA that are at low estimated CVD risk according to SCORE.

Moreover, to reduce the problems of misalignments, local realignment of reads with InDels have been suggested and to minimise the detection of false positives due to other factors, stringent criteria for post-alignment filtrations needs to be applied [ 25].