It is possible that OP treatment of ovarian tumor-bearing mice may require stringent OP dose dependency in order to disrupt tumor vasculature, perhaps by blocking epsins as suggested in our previous report [34].
Both methods, however, suffer from limitations, including user-dependency and stringent technical requirements [ 4, 6- 12].
1,126 shRNAs targeting 259 chromatin regulators were assessed individually for effects on the viability of B-ALL cells in culture, which led to the identification of 16 dependencies after applying stringent scoring criteria.
It depends how stringent the cap is.
However, as discussed above, the presence of technological path dependencies and lack of stringent climate policy framework conditions limit incentives for structural change.
In the past decade, through the use of wind and solar power, recycling of wastewater throughout eco-suburbs, linking up urban infrastructure in synergistic ways, and imposing stringent building codes, Swedes have cut their oil dependency and drastically reduced their sulfur and CO2 emissions.
At the same time, since the most stringent permutation based null-model predicts non-linear dependencies of individual occurrence probabilities on vertex degrees, assuming such linearity in statistical models of co-occurrence will be linked to loss of stringency.
The nucleic acid-sensing platform was designed to overcome the need for stringent temperature control during transportation or storage of reagents and reduces the dependency on skilled personnel by decreasing the overall assay complexity and hands-on time.
Using the less stringent correction for multiple testing [ 24] (which does not take into account dependency between tests) compensates for this loss of recovery rate, but comes at the expense of a much larger linked regions (see Additional file 2: Figure S2).
This feedback is mediated, at least in part, by the nucleotide dependency of rRNA transcription, and by the accumulation of uncharged tRNA, through the stringent response [10], [13], [15], [30].
