Suggestions(5)
Exact(7)
Neither drug caused substantial downregulation of genes at the stringent cut off value (log2 fold change >2).
The use of a much more stringent cut off (p < 0.00001) still identified 219 to 229 transcripts.
Considering the cost implications of providing one to one CCBT sessions, a more stringent cut point for high risk may be more useful.
At a more stringent cut off level, still 63% of the sequences could be determined within ±10○C and 6% within ±5○C.
The findings were replicated in sensitivity analysis using an alternative, less stringent cut point of >18 to define high FRS (Supplementary Table 2).
In addition, less stringent cut points were assessed, as recommended by the ADA (A1C <8.0%[<644 mmol/mol], BP <140/90 mmHg).
Similar(53)
Church of England and Catholic church representatives, and leading neonatalogists, criticised the guidelines from the 14-strong Nuffield committee, for setting out too stringent cut-off points.
Stringent cut-offs were used.
We expected that a less stringent cut-off (e.g., 40%) would allow too many negative sequences in the phyloPWM, and that a more stringent cut-off (e.g., 90%) would not introduce enough variability.
However, as outlined above, our stringent cut-off is not expected to identify all of the RNA-binders.
Only interactions fulfilling a stringent cut-off criterion were used in order to ensure high data quality.
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