We used Visual Basic 6.0 and Oracle 8i to manage our data, with stringent range, consistency, and logical checks.
The data collected in the field on a pre-designed data collection form was entered, collated and stored in the relational database management system developed in Oracle 8i with stringent range, consistency and logical checks.
Recent regulatory guidelines, among which the U.S.FDA draft guidance is the most stringent, demand consistent dose delivery from an inhaler throughout its life and consistency of doses from one inhaler to another.
For Coefficient of Variance (COV) [a more stringent measure of response consistency: (100 x variability)/latency], response consistency was significantly greater when children were tested on medication compared to their performance off medication F 1,15) = 32.28, p < .00, η = .68.68
The authors concluded that with stringent preprocessing and sequence matching, consistency and reproducibility among platforms and laboratories was good for highly expressed genes and variable for genes with lower expression.
Each combination of filtering and algorithms produced some viable candidates, but the most stringent filtering generally showed the best consistency with PCR validation results.
This study also identified activation of the MAPK pathway in cSCC compared with AK and normal skin, highlighting the power of stringent laser capture microdissection for improved consistency across studies.
It must be noted that our measure for topological consistency (full compatibility) is highly stringent, since a single mismatch would render two trees inconsistent.
Therefore, the requirement of consistency has to be imposed with minimally stringent cut-offs [ 17].
More stringent guidelines, based on current best practice, could significantly improve rigor and consistency of toxicology and carcinogenicity assessments.
