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The most effective groups in the sector recognize the importance of stringent compound management [17,18] and have fully integrated capabilities in chemoinformatics, synthetic organic chemistry and/or medicinal chemistry.
If too many results are found, one may rerun the analysis with a higher (more stringent) compound similarity threshold, and/or a lower (more stringent) affinity cutoff (input as nanomolar).
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In this stringent analysis, the compound null hypothesis can only be disproved if all of the intra-tract associations are significant.
The produced ammonium should be removed in accordance with the stringent rules for nitrogen compounds in wastewater effluent (http://ec.europa.eu/environment/water/water-urbanwaste/index_en.html).html
These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position.
For the other three compounds, no more stringent FDR was applied because their changed gene numbers were much less than 2000.
In this stringent model, treatment with 50 mg/kg compound 1 (i.p).
To confirm that this was a sufficiently stringent arbitrary criterion to identify toxic compounds, we treated cells with 1 μM of the 11 kinase inhibitors that scored positive as above and then assessed 6 days after treatment whether cells exposed to these compounds were still viable.
Northeast and Midwest states have implemented model regulation of mercury emissions, and regulations in five states set exposure limits to volatile organic compound emissions that are more stringent than US Environmental Protection Agency standards.
However, concern over its negative health effects have led to stringent regulation of all gasoline's aromatic compounds.
Due to stringent environmental regulations, the reduction of aromatic compounds present in diesel fuel, precursors of particulate matter, is becoming one of the most important technologies in petroleum refining industries.
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