In this protein maturation process, nascent polypeptides need to pass stringent checkpoints monitored by a sophisticated quality control program.
Normal cells with stringent checkpoints respond to nutrient deprivation by arresting cells in G0, from which the majority can be recovered several weeks later.
After much dilly-dallying we eventually made it to the line, which consisted of girls from the Home Counties, an array of boyfriends who all looked like Rick Ross himself, and three separate and very stringent security checkpoints.
We attributed this increased cytotoxicity of NU1025/C-1305 combinatoon to a partial re-activation of wt p53 pathway in drug-treated HeLa cells and a more stringent cell cycle checkpoint control during G2/M transition that was associated with the enhanced cell death by mitotic catastrophe [48].
So while Iraqi soldiers now stand at checkpoints, Americans are still watching from nearby, and intelligence about a possible terrorist attack has made the checkpoints more stringent than usual this week, an Iraqi military spokesman said.
For example, using the same panel of cell cultures, we have recently reported that the G2 checkpoint is more stringent in longer-lived species [ 7].
When human and mouse fibroblasts were damaged during S phase, mouse cells were more sensitive as demonstrated by increased micronuclei formation, and the G2 checkpoint arrest was less stringent as judged by the number of mouse cells that proceeded into G1 in the face of DNA damage.
Sentries of old might have considered the requirement for someone to whisper the word "Methuselah" to get past a checkpoint to be pretty damn stringent, but as soon as "Methuselah" was forgotten or passed on (deliberately or inadvertently), they may as well have abandoned the checkpoint and put up a sign saying: "Come on in".
The rival armies set up checkpoints and extorted money from the local people, who became fed up and in many cases welcomed the stringent order imposed by the conquering Taliban.
