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However, as discussed, our stringent case selection criteria yielded a more uniform data set for analyses.
This is a stringent case of n-fold cross-validation where n equals the total number of sequences.
It is possible that our use of a stringent case definition for diarrhea may have missed an association with more mild gastrointestinal symptoms such as nausea.
In this study, the diagnosis of asthma was based on stringent case definitions.
Another limitation is the reliance on recall for thyroid diagnosis, although we also investigated a more stringent case definition of report plus medication use and obtained similar results.
We therefore defined acute gastroenteritis using a similar, but more stringent case definition than that used by the original outbreak team.
Similar(43)
It is known that except for a few stringent cases, additive error of any 2-dimensional declustering scheme is at least one.
It has been pointed out in the literature, that such shortcomings strongly call for more stringent case-control studies of the type here reported [ 51, 52], and from which further investigations on the individual level are then of equally large interest.
Aspen achieves the moderate and stringent cases with 4 °C and 5 °C, respectively, which is approximately the upper range of the regional multimodel projections.
The design offers a stringent test case for scoring a cross-talk between A residues with those of T that are diagonally placed on the opposite strand at either −3, −2, −1, +1, +2, or +3 pairing frames.
This condition seems too stringent in cases where a beneficiary desperately needs a benefit but is not able to accept it, say, because of incapacitation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com