The Stonewall Inn is already part of the Greenwich Village Historic District and was listed on the National Register of Historic Places in 1999 but the city landmark designation would apply more stringent standards on alterations to the property.
Despite this, significant alterations were still observed for endometroid (e.g. TPM3) and given the stringent criteria; these are likely high confidence alterations.
The commission imposes stringent regulations that curtail or prohibit significant alteration of the architectural features of landmarks.
Thus, in order to avoid false/erroneous classification of miRNAs as up- and down- regulated in mucosal biopsies of IBD patients, only miRNAs with alterations of expression that fitted stringent thresholds (2−ΔΔCT>5-fold and 2−ΔΔCT<0.2-fold, respectively) were considered.
Despite these limitations, by applying stringent selection criteria, our study identified significant alterations in several important lipid classes associated with markers of inflammation and hepatic function in HIV patients on PI-based ART.
Those unidentified contigs could result from the following aspects: the limited number of available human genomes; the stringent selection criteria in each step; sequence alterations in mRNAs from RNA editing [ 28]; variations in transcribed regions (e.g. SNPs, indels, structural variation); or the assembly errors in contigs due to the limitation of assembly algorithms [ 29] and etc.
The more stringent definition of the absence of segmental chromosome alterations, for which the status at all three chromosome arms had to be known, when compared with the definition of a segmental type, for which an alteration of any of the chromosome arms was sufficient, might lead to an underrepresentation of non-segmental cases.
Even after adjustment for conventional risk factors and stringent type I error reduction techniques, two of the NOS3 SNPs shared significant associations with ABI, suggesting that alterations in NOS3 may indeed influence inter-individual variation in ABI.
Regions of differential copy number alteration between SCLC and NSCLC genomes were identified using a stringent multistep filtering process.
However, as these end points are regarded as stringent, analyses at molecular level could provide a broader understanding in the alteration of biological pathways, including responses induced from environmental stressors [ 28].
