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Because privately underwritten studies rarely replicate the stringency of the research used in the F.D.A. approval process, off-label uses are simply not as reliable as their "on-label" counterparts.
Studies have shown that factors influencing participation in CCTs include participant demographics, insurance coverage, awareness of CCTs, potential side-effects of the CCT, trial setting, concern with the research process, complexity and stringency of the research protocol, and physician attitudes towards the trial [ 20- 24].
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Depending on the stringency of the legislation, many research and audit functions such as health services research and cancer registries may be at risk.
The stringency of the variance allowed for clustering is customizable, thereby affecting the number of peaks that are clustered.
What's more, the stringency of the rules governing each of these dimensions can vary all over the map.
Depending on the stringency of the new E.P.A. rules, they could be even more consequential than his 2012 automobile regulations.
Relative to this vast choice looming a few decades ahead, squabbles over the stringency of the Kyoto emission targets are foolish.
Nevertheless, the framework of parliamentary democracy survived the continuing economic stringency of the 1980s.
The stringency of the FFP punishments gave the regime an authority backed by European law.
"The stringency of the rules matter tremendously for outcomes.
Surgical outcomes typically were not related to stringency of the hospital credentialing environment.
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