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In the United States 10 to 20 percent of men and 5 to 10 percent of women at some point in their lives will meet criteria for alcoholism, depending on the stringency of the criteria employed.
Near the end of Canada's role in the Afghanistan War, concerns were raised about the stringency of the criteria that needed to be met to receive the Victoria Cross.
This number of 767 pseudogenes is likely an underestimate given the stringency of the criteria used here.
Differences in protocols, platforms, and number of replicate measurements can lead to significant differences in the stringency of the criteria used for detecting differential expression across experiments.
First, the "stringent orthologous single-gene families", identified "based on reciprocal best Blastp-hits (E-value cutoff 10^-40 10^-40 amongalls within one orthologous family" (Methods) are pairs to false negatives due to the very stringency of the criteria.
This distance is somewhat greater than that estimated for several monocotyledenous [ 15, 21] and dicotyledenous [ 22] species, perhaps because of the greater stringency of the criteria and the lesser size of the sequence dataset.
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Despite the stringency of these criteria and the highly active disease of the patients in the TAMARA study with DMARD pretreatment, TCZ induced remission rates in over a quarter of patients.
The lists of the ORFs considered for each of the metabolic functions, for different stringencies of the criteria (i.e. cut-off in E-values) is presented in Additional file 2, whereas the data presented in Additional file 1 refer to a cut-off E-values of 1E-50.
The stringency of this criterion determined the number of metabolic functions assigned to ORFs, as well as the number of ORFs considered for each function (see Additional file 3).
The filtering analysis demonstrates the effect on coverage and the number of targets found when altering the stringency of the filtering criteria.
The stringency of the remission criteria determines achievement of the best possible functional improvement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com