Sentence examples for stringency methods from inspiring English sources

While high stringency methods can be valuable for an individual miRNA [ 40], TargetScan/PicTar modifications do not appear to enhance the available algorithms in a broader, genomic context.

To ensure we had not missed any important binding partners, we also performed an E12488-651 library screen using a reduced-stringency method that is designed to favor the detection of lower-affinity interactions.

To estimate the prevalence of NATs in Plasmodium, we established two sets of thresholds with different stringency (see Methods for details).

Furthermore, interestingly, we correctly identify the stage of symbiosis for 92%–100% of the proteins contained in modules depending on stringency (see methods and Fig. 3c).

In order to increase the probability of detecting potentially low levels of G72, washing conditions were kept at a low stringency (see Methods), and phosphorimager exposure times were increased to up to three days.

As for the largest WES study in schizophrenia to date (Purcell et al. 2014), and our previous CNV studies (Pinto et al. 2014; Costain et al. 2013; Silversides et al. 2012), increased stringency of methods and approach, including quality, rarity, and deleteriousness of variants, generally strengthened the findings.

In this study, the prevalence of HPV DNA was examined in a range of premalignant and malignant cutaneous tumours from 50 immunosuppressed patients (47 renal allograft recipients plus three cardiac allograft recipients) and 56 immunocompetent patients using Southern hybridisation as a low-stringency screening method and type-specific polymerase chain reaction (PCR) assays for eight HPV types.

Additional file 5 shows the number of bases that covered as distinct nucleosomes and the number of bases covered as fuzzy nucleosomal regions identified at the different stringency levels (See Methods).

Because the pyrophosphatases and the TIM barrels mentioned above are widely distributed, we decided to test the stringency of the method with rare proteins.

The order of FP rates (BLASTP > SBH > RBH) is concordant with the stringency of each method.

However, when we increased stringency of our method (γ=99.9 %), cn.MOPS was outcompeted.