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This provides further evidence that annotation enrichment is not due to some artefact, as this pattern is consistent with the proportion of true GWAS hits increasing as p-value stringency increases.
Sensitivity decreases as SNP detection stringency increases.
a) Delta values from 0.2 to 1.6 for MSA analysis show decreasing FDRs as stringency increases.
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The results were largely robust to variation in this threshold, with the primary effect being that decreasing the stringency increased both the FDR and the number of hits.
When keyword stringency increased the number of useful publications decreased to a workable level (Table 1).
Consistent with previous findings, increasing detection stringency increased the proportion of genes in common between the platforms [ 32].
When the filtering stringency increased from F0 to F4, the number of SNPs surviving selection in silico decreased abruptly.
In contrast, WGS coverage performance decreased sharply as coverage stringency increased, finishing only 10%% of genes at ≥20 × .
As stringency increased, 40 83% of proteins were rejected, and the relative nematode branch length (to the arthropod and vertebrate branches) dropped from 16% to 0%.
Large values of T (high stringency) is appropriate for gene expression [ 15], while small values of T (low stringency) increase the weighting of subtle differences in expression, and may be required to discriminate arrays at the pathway level, where the coordinated effects of multiple genes are under consideration.
In conventional VI assays with polyclonal reagents, such as patient sera or plasma, IC90 values are the parameters usually considered for measuring neutralization as this increased stringency parallels increased specificity.
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