Measuring the decay of SOCS3 mRNA after blocking new RNA synthesis with actinomycin D showed that silencing YTHDF2 strikingly elevated SOCS3 mRNA stability (Fig. 6f).
Specifically, both naïve and activated T cells derived from genetically engineered mice that lack the Sts proteins display strikingly elevated levels of tyrosine phosphorylated, ubiquitinated proteins following TCR stimulation.
We found that galectin-9 levels were strikingly elevated in HCV patients (median 841 pg/ml in HCV vs. 0 in normal controls, p = 0.0005, Figure 1).
Egr-1 expression is strikingly elevated in the VSMCs of atherosclerotic lesions [24] and plays critical roles in regulating VSMCs growth and intimal thickening after vascular injury [25].
Pparg transcript levels are strikingly elevated in Tsc2-deficient MEFs, even at day 0 of differentiation, and remain high throughout adipogenesis (Figure 4A).
Accordingly, mRNA levels of several p53 target genes, which are known to be up-regulated in senescent cells [52] [54], e.g. CDKN1A (p21), GDF15, and SERPINE1, were strikingly elevated in primary AFCs compared to AFiPSCs and ESCs.
As shown in Figure 6, only the major palladin isoform (85 90 kDa) is detected in all the tumor samples, and palladin levels were strikingly elevated in all tumor samples when compared to the control samples.
MCP-1, a chemokine with similar function, showed no such distinction of the individuals with rare alleles, but those with the R202Q polymorphism were strikingly elevated (p = 0.004, legend Figure 2) compared to FMS patients generally, and all FMS patient and family groups were elevated relative to unrelated controls.
Risk for chronic kidney disease is strikingly elevated in the setting of HIV infection.
Strikingly, elevated pERK levels were observed only in the somata of RSK Δ58/1 motoneurons.
Women who had all three conditions showed a strikingly elevated risk than women without any comorbidity (HR 4.13 [95% CI 2.76 6.18]).
