Strikingly, mice deficient in either DNA-PKcs or WRN alone do not show aging phenotypes unless they are under a short telomere background.
Strikingly, DDB1 deficient bone marrow cells from polyI C injected Ddb1 f/f::Mx1Cre + animals were not able to form colonies in cytokine-supplemented in vitro culture as well as in spleens of host mice.
Most strikingly, P0-deficient motor nerves displayed an ectopic nodal expression of the Nav1.8 isoform, where it is coexpressed with the ubiquitous Nav1.6 channel.
Strikingly, Irga6-deficient MEFs (Irga6−/−), in which chlamydial growth is enhanced compared to WT MEFs, showed no response to IFNγ even though all the major IRG proteins studied still localized to inclusions.
Strikingly, SMAR1-deficient cells failed to exhibit G2/M checkpoint, and instead showed elevated apoptotic population.
Strikingly, respiration-deficient mutants are competent for this starvation-induced mitophagy, suggesting that oxidative stress is not a general prerequisite for degradation of mitochondria.
Strikingly, LC3-deficient cells showed marked reduction in tumor volume and weight gain compared with control shRNA bearing MDA-MB-231 cells in nude mice xenograft model.
Most strikingly, Bad-deficient animals were protected from the lethal effects of hepatitis elicited by D-GalN priming and subsequent TNF injection.
Strikingly, ATG5-deficient mice are highly susceptible to M. tuberculosis infection, highlighting autophagy as a major determinant of host resistance to M. tuberculosis infection in vivo (Castillo et al., 2012; Watson et al., 2012).
Strikingly, Artemis-deficient fibroblasts show a defect in RPA and Rad51 foci formation similar to that of A-T cells, substantiating our conclusion that Artemis and ATM promote HR in G2.
