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Two were strikingly abnormal: she had almost no copper in her system; and her zinc level was through the roof — more than twice the normal amount.
Although this passage can be explained in terms of normal harmonic analysis, it was in itself strikingly abnormal for its time.
By contrast, meprin β knockdown animals exhibited strikingly abnormal disorders of the whole trunk and tail in early development (Figure 2D).
In particular, energy homeostasis is strikingly abnormal in ALS patients since both sporadic and familial ALS patients present with increased energy expenditure (hypermetabolism) and hyperlipidemia [5] [8].
Strikingly, abnormal PrP appears to deposit in the myelin sheath of myelinated axons.
The few upper layer neurons that reached their normal location exhibited strikingly abnormal orientation of basal dendrites.
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Moreover, inhibition of MEK-ERK signaling by U0126 strikingly diminished the abnormal increases in AP-1 activity, COX-2 expression and PGE2 production in TDP-43-deficient microglia.
In contrast, almost all (93%) of the siTACC3 injected oocytes arrested at meiosis I contained abnormal spindles, strikingly resembling the structures observed in TPX2 depleted oocytes expressing YFP-TPX2ΔN (Fig 7A bottom lane).
Those abnormal mitochondria were strikingly reminiscent to the mitochondrial spheroids recently described in cells where mitophagy was blocked.
In DKA, although the concentrations of these acids are less strikingly elevated, they are still abnormal in the majority of patients when compared to controls.
In addition, muscle down-regulation of either Sac1 or DVAP leads to a strikingly aberrant synaptic morphology and abnormal localization and distribution of several postsynaptic markers, including adducin and β-spectrin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com