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The most convincing evidence for such a notion comes directly from the clinic, in particular the striking clinical responses to anticytokine biological therapy [ 2].
The most striking clinical features, elevated levels of glucose in the blood and increased excretion of glucose in the urine, are due to the patient's inability to metabolize glucose normally.
Recent data and striking clinical responses demonstrate the power of this new type of therapy.
While chimeric antigen receptors (CARs) have been used extensively to redirect the specificity of autologous T cells against hematological malignancies with striking clinical results, studies of CAR-modified natural killer (NK) cells have been largely preclinical.
The most striking clinical features of infection with HCV are its extraordinarily high propensity to develop persistent viremia (∼80%) [2], and the high proportion of patients who develop long-term complications including cirrhosis and liver failure [3], [4].
These diseases share striking clinical similarities that complicate the diagnoses.
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Finally, it is striking that clinical quality in Northern Ireland is higher than in the rest of the UK.
Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics.
This is at striking contrast with clinical decision making of ICU physicians, which is felt to be in line with these crucial outcomes.
The striking results from clinical trials with crizotinib, the first ALK inhibitor evaluated, allowed the accelerated approval of crizotinib from the USA Food and Drug Administration FDAA).
Immune checkpoint inhibitors targeting the programmed cell death receptor/ligand 1 (PD-1/PD-L1) pathway displayed striking and durable clinical responses in patients with non-small-cell lung cancer (NSCLC).
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