Sentence examples for strictly mediated from inspiring English sources

These findings suggest that first pregnancy effects on later life breast density and cancer risk are not strictly mediated by later life sex steroid hormone levels.

LPA induced a rapid and transient synthesis of Egr-1 that is strictly mediated via Gαi/Src/p42/44 MAPK pathway with no involvement of the Gαq/11/PLC/PKC or the PLD/PI3 kinase/Akt pathways.

Egr-1 expression was strictly mediated via Gαi/Src/p42/44 MAPK pathway; no involvement of the Gαq/11/PLC/PKC or the PLD/PI3 kinase/Akt pathways was found.

The unique multi-threshold pattern in IgM-BCR activation is not strictly mediated by the outside-in or inside-out activation of the integrin molecules as addition of neither ICAM-1 nor FAK inhibitor changed that patterned dependence on mechanical forces in IgM-BCR activation.

The proportion of patients whose reactions are strictly IgE mediated in nature is unknown.

Although verification of the siRNA target gene can be easily done by generating multiple siRNAs targeting other regions of the gene, this strategy becomes problematic if the phenotype caused by the siRNA is mediated strictly by an "off-target" effect.

In mature human ECs, miR221/222 exhibit strictly antiangiogenic properties mediated by many targets.

As expected, the MMP1 inhibitor (with MMP8 inhibitory activity) protected mice against CLP, but failed to protect PAR1 knockout mice against CLP, which would suggest that the activities of MMP1 are strictly PAR1 mediated.

Hence it is important to demonstrate that the formation of the G-quadruplex structure on the proximal promoter region of the RET gene is strictly required to mediate the inhibitory effect of berberine.

Thus, the repression was mediated by a strictly maternal (i.e., extrachromosomal) effect.

Interestingly, endothelial cells are strictly dependent on these consensus signals mediated by the extracellular matrix for adhesion, migration and survival (Cheresh & Stupack, 2008), which may explain their overt collapsing response to Uncl-Sema3E stimulation.