The PPI network showed that these proteins were strictly interacting with each other.
Indeed, its homologous position in non-Mecopterida USP and in vertebrate RXR is a strictly conserved lysine that interacts with the partner of heterodimerisation.
The building instead of being "sealed"and its environment kept strictly controlled, it "opens" and interacts with its surroundings.
All of the ligands contain a carboxylic acid or phosphate group that interacts with three strictly conserved arginine residues (Arg 118, 292, and 371) [14] in the so-called acid binding sub-pocket of the binding site.
Mde2, whose expression is strictly regulated by the replication checkpoint, interacts with Rec15 to stabilize the SFT subcomplex and further binds Rec14 in DSBC.
These investigations suggest that olanzapine binds in a polar region of the cytosolic part of the transporter, and interacts with residues R129, strictly conserved in all GLUTs, and N136, conserved in only a few GLUTs, including the insulin-responsive GLUT4.
Calcineurin activity is strictly regulated by regulator of calcineurin 1 (RCAN1), which interacts with calcineurin subunit A, inhibiting calcineurin activity.
This residue is strictly conserved in members of the main kinase superfamily and interacts with the α- and β-phosphates of ATP; mutating it strongly impairs kinase activity.
The ligands show discrete binding to specific receptor(s); for example, VEGF-A interacts with VEGF-R1 and VEGF-R2, whereas PlGF interacts strictly with VEGF-R1.
DXR contains a strictly conserved residue, Trp203, within a flexible loop that closes over and interacts with the bound inhibitor.
