In a population with small effective size, the variants with small selection coefficients, particularly slightly deleterious mutations, will act as strictly neutral alleles to drift to higher frequencies and even to reach fixation [45], [46].
In any case, it is important to strictly control hypertension, since hypertension per se has a deleterious effect on the microvascular lesions and plays an aggravating role in HUS.
The antigenic peptides derived from cancer-germline genes, also called MAGE-type antigens, therefore appear to be strictly tumor-specific and their use as immunotherapeutic targets should not be deleterious to the patient.
If not strictly controlled, this potent defense system can activate autoimmune and inflammatory stress reactions, with deleterious consequences for the organism.
("Was his face more boyish, or masculine?" "How much did his ears stick out?") The final sketches are strictly personal, but the process is universally fascinating; romantic and criminal trauma are revealed to have similarly deleterious effects on memory.
Relatedly, we have assumed that the fitness of cells within the tumour is strictly relative; this leads to the least fit cells being rapidly outcompeted by fitter cells, and so clones carrying deleterious housekeeper mutations are rapidly driven to extinction.
"It had a deleterious impact".
