As the natural sources of heparin are diverse and the production of raw heparin is not under strict control, the variability in the chemical profile of raw heparin is not surprising.
The occasional presence of such immune markers could be due to technical differences in sample management, less strict diagnosis or biological variability in certain cases, but has no diagnostic value.
Both of these approaches place strict limitations on shape variability, since a given set of local structures or landmarks must be detected on all samples.
In this report we analyzed the significance of BG stability, or variability under strict control of BG, by the use of an AP.
Our results support that, in premenopausal women, it is imperative to apply a strict control of the biologic variability of hormones and/or other biologic variables to test potential associations with specific outcomes.
With our small sample size, success rate estimates of qualitative variables have a high variability; statistically significant results or strict dose-response patterns cannot be expected for qualitative parameters such as remission or mucosal healing.
I think it is this dialectic principle, resulting from the dichotomy of great variability coexisting with strict conservation – not only on the molecular level but also on the organism level – that makes molecular biology a particularly fascinating discipline.
Additionally, strict homogenization of experimental parameters reduces variability within test groups and is therefore believed to increase reliability of animal experiments [5, 6].
However, at this level of significance the expression stability controls are less strict and the inherent increased expression variability of signal transducers prevails in this tier.
This suggests that strict protocols for diuretic therapies reduce variability in patients' response.
