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As already reported by Keßler et al. [25], this genetic marker co-segregated in an F2 panel with symptoms of central diabetes insipidus in LAB mice and, partially, with anxiety-related behavior, further confirming the strict linkage between the promoter deletion Δ(−2180 2191) and C(40)T.
However, the data confirmed that the HR is in strict linkage disequilibrium with HS.
While we could have sequenced every individual for the mtATP, the strict linkage and reduced variation of this gene did not warrant the additional resources, since no significant information advance was likely to be gained [ 40].
Using this assay we confirmed the previously described strict linkage of the (GTCA) sequence with p.D314 + L218 CTA) coding sequence alleles, and the strict repulsion of the (GTCA) 5′ sequence with the p.N314 and p.D314 + p.L218 TTA) coding sequence alleles.
Since the SNPs in the loci replicated in the Demirkan et al. dataset had relatively low r values with the SNPs reported in the Illig et al. dataset, we could not perform a traditional meta-analysis where strict linkage disequilibrium criteria are applied.
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Strict criteria to accept linkage were essential to avoid making an incorrect link.
There is not a strict hierarchy for the linkage keys, so in some cases there may be more than one appropriate key for the comparison.
In order to widen the engineering application of 3D overconstrained linkages, their strict overconstrained geometric conditions are expected to be eliminated for improvement of fabrication error tolerance so as to facilitate mass production, which requests to find the non-overconstrained forms of the overconstrained linkages.
We observed several pairs of loci in significant linkage disequilibrium after strict Bonferroni correction in each sample (Table 3).
LD: number of locus pairs in significant linkage disequilibrium after strict Bonferroni correction (nominal level: 0.05, adjusted p: 0.00023).
Using a variety of record-linkages procedures, under strict control to protect individual privacy, we collected additional information for each study member.
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