Their strict expression on the surface of malignant cells has led to several immunotherapeutic trials targeting some of these members (Sang et al, 2011; Meek and Marcar, 2012).
We selected for genes exhibiting strict expression patterns at early stages of male gametophyte development with no or low signals in mature pollen.
Together, these data indicate the importance of strict regional expression of Cdx1 for the maintenance of the intestinal stem cell compartment and normal boundaries within the gut.
Note that in contrast to CUC3 for which a transcriptional fusion is sufficient to recapitulate boundary expression, CUC1 expression is restricted to the boundary via the post-transcriptional action of miR164, and thus strict boundary expression of CUC1 can only be observed in a translational fusion line (Sieber et al., 2007; Laufs et al., 2004).
Genes in bacteria may be organised into operons, leading to strict co-expression of the genes that participate in the same operon.
Such transducers appear to be provided with stricter expression stability controls, and such controls may override the putative increased variability of signal networks.
Our aim was to identify CRMs (and their associated potential transcription factor binding sites (TFBSs)), responsible for a strict temporal expression profile of sets of co-expressed genes during adult heart formation in Drosophila.
Only some of the novel putative imprinted DMRs could be confirmed to show monoallelic expression, and others did not show strict parent-of-origin expression in all placentas (Table S5 in Additional file 2).
In Jean-Auguste-Dominique Ingres, idealistic Neoclassicism found an exemplary expression of strict linearity, and the pencil drawing became a downright classical form.
The bill had prompted a strong outcry in the media and among government critics, and Mr. Medvedev's request appears to represent a rare example of public opinion influencing policy in Russia, a country with strict controls on free expression of divergent political ideas.
