Sentence examples for strict corrections from inspiring English sources
Applying strict corrections for multiple testing would make investigations like the present impossible to perform, because a sample big enough to withstand such a correction procedure would probably never be possible to obtain.
The reported p-values have not been corrected for multiple testing, but a strict correction is not critical given the biological plausibility implicating these genes in NTDs.
By means of a less strict correction (FDR), they exhibited significant (p < 0.01 FDR corrected) bilateral activation during approximate calculation in the middle frontal gyrus (MFG), intraparietal sulcus (IPS) and anterior cingulate gyrus (ACG).
This directed specificity is not reflected in current, overly strict correction methodology.
Particularly some of the cis effects constituted large effect sizes that are likely to be biologically relevant and survived strict correction for multiple testing.
Therefore, the chance of a false positive result is significantly less when the KEGG database is used and less strict correction for multiple hypothesis testing is required.
Strict correction, such as Bonferroni correction that assumes independent multiple hypothesis testing, would be unnecessarily strict because we often see strong correlation in signals across time, frequencies and neighboring electrodes.
This significant association even withstands a more strict correction of treating all 118 SNPs as independent tests (0.05/118=4.2×10-4).
Since scores on the four cognitive measures were correlated, strict correction for multiple comparisons using, for example, a Bonferroni correction, was not suitable.
Our sample size was larger with more strict correction procedures for multiple testing which may account for these genes not reaching the statistical threshold in our analysis.
The major problem is the strict correction for multiple testing needed to exclude false positives after performing hundreds of thousands, or even millions, of tests.
