This use of nucleic acids is enabled by their strict base pairing rules, which cause only portions of strands with complementary base sequences to bind together to form strong, rigid double helix structures.
These results suggest a general rule for predicting piRNA targeting regions on mRNAs, which requires a relatively strict base pairing at the 5′ end of piRNA with mismatches of < 3 in the following 20-nt sequence.
However, both our computational analyses and reporter assays suggest that a somewhat less strict base-pairing rule might suffice for MIWI/piRNA-mediated degradation of mRNA targets in the cell.
Bragg ran a strict regime based on the conviction that the subject of the film was the artist not the director.
Classical behaviourism was further characterized by a strict determinism based on the belief that every response is elicited by a specific stimulus.
He rose through the ranks of the Pakistan Taliban and in 2008, headed its vice and virtue department, enforcing strict edicts based on a narrow interpretation of Islamic texts.
However, a strict definition based on the output mode may not be appropriate.
This latter selection criterion is preferred over a more strict one based on the illumination of the spacecraft.
This silence is remarkable for one whose Calvinism dictated belief in strict predestination based on the sufficiency and necessity of grace.
Complete and radical debridement in the first stage, proper antibiotic therapy as well as strict weekly based clinical and laboratory follow ups helped in achieving a desirable outcome.
