But they are complementary approaches, which cannot completely replace animal research and are not even strict alternatives.
We would also stress that specificity and cross-reactivity should be considered endpoints of a spectrum rather than strict alternatives, and we would hope that our approach encourages thinking about quantitative predictions for the level of cross-reactivity we might expect lymphocytes or antibodies to exhibit.
His strict-construction alternative, using apostrophes to indicate possession -- "against homosexuals', or any other group's, promoting" -- is correct but clunky.
Firstly, OrthoMCL, our clustering algorithm of choice, is relatively strict compared to alternative clustering algorithms [ 58], potentially leading to false negative results.
Due to strict emissions standards, alternative energy sources must be found for vehicles in the future.
Building on Prior's metaphysical intuitions, Adams [1981] sketches an alternative, strict actualist semantics for modal discourse and a corresponding logic.
In addition, the classification of the uORFs (alternative, strict, or overlapping) in these 5'UTRs is sometimes ambiguous (see Additional file 3 for an example).
In addition, lenders wound up imposing stricter parameters for alternative loans.
We also tested the impact of applying alternative (stricter) cut-offs; these did not affect our general findings.
This binary distinction between universal and nonuniversal orthologous groups as well as between single-copy and multicopy orthologous groups was chosen for simplicity and consistency over alternative (stricter and possibly more intuitive) categorizations presented in the Supplementary Material online that support the same conclusions (supplementary figs. 1– 3, Supplementary Material online).
