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Experiences from the Scandinavian countries – which from time to time have combined relatively generous social insurance payment levels with strict activation requirements – indicate that activation is an effective tool for containing moral hazard problems.
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The genetic logic devices described here have particular advantages including the tight unactivated off state attributed to the underlying σ-dependent strict transcriptional activation requirement.
It is therefore relevant to investigate the functional consequence of strict co-activation of the NMDA-Rs and group-I mGluRs.
Since complement can also lead to host tissue injury and inflammation, strict regulation of its activation is important.
Assuming a strict mapping between brain activation and functional involvement, pseudoword reading mainly relies on the assembling and processing of sub-word units.
Taken together, these data suggest that myotubes are unable to undergo apoptosis in response to cytochrome c due to the strict control of caspase activation by endogenous XIAP.
The remaining subjects did not satisfy our strict criteria even though activation was evident if we increased the distance from the group peaks (>8 mm) or lowered the statistical threshold (P > 0.1 uncorrected).
Activation of the strict late viral UL38 gene is dependent upon preceding sequential activation of immediate early and early viral genes and cellular transcription factors [17] and the UL38 promoter (UL38p) has been demonstrated to be selectively activated in cancer cells in the context of replication competent γ134.5−/− HSV mutants [18].
Cardiac myocytes express low levels of Apaf1, and a consequence of this low Apaf1 activity is the engagement of strict control of caspase (casp) activation by endogenous XIAP.
The aim of this study was to investigate whether strict glucose control modifies complement activation in this setting and to analyze the route of complement activation.
Their extraordinary physiological "success" is due to concomitant broad substrate specificities and strict regulation of their expression, activation and inhibition levels.
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