Exact(8)
An intrinsic mechanical stress sensing system is embedded in the Z disc of cardiomyocytes, and defects in stretch responses can lead to heart failure progression and associated increases in wall stress.
How these effects mediate dynamics of stretch responses in intact cells remains unknown.
In the human thumb, there is evidence that long latency stretch responses reflect a trans-motor-cortical long loop response and that corticospinal tract malfunction can modify contralateral muscle response after unilateral stretch [65].
Medium-latency stretch responses of lower limb muscles in humans are thought to be transmitted to the spinal cord by secondary spindle afferents and relayed through an oligosynaptic spinal pathway [60], [61], [62], [63].
In this condition, stretch responses in the gastrocnemius were delayed, whereas LLRs in the tibialis anterior were markedly reduced.
This study suggests that important stretch responses of collagen made possible by collagen crimping may be markedly altered by morphologic changes during aging/degeneration and may contribute to the early tissue changes involved in annular tears.
Similar(52)
At the cellular level, the CSD attenuates cardiomyocyte hypertrophy, reduced oxygen diffusion distance and downregulated stretch response proteins.
These typical features of the nominal stress versus uniaxial stretch response were found for all samples.
The small muscle protein (smpx) is encoded by a recently discovered X-linked stretch response gene [ 16].
The NES signal treatment reverses the cardiac maladaptive fetal gene program and normalizes expression of key sarcoplasmic reticulum Ca2+ cycling and stretch response genes.
We propose that miRNAs may regulate some of the stretch response, and therefore hypothesized that miRNAs would be differentially expressed between cyclically stretched and unstretched rat alveolar epithelial cells (RAECs).
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