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The NES signal treatment reverses the cardiac maladaptive fetal gene program and normalizes expression of key sarcoplasmic reticulum Ca2+ cycling and stretch response genes.
At the cellular level, the CSD attenuates cardiomyocyte hypertrophy, reduced oxygen diffusion distance and downregulated stretch response proteins.
These typical features of the nominal stress versus uniaxial stretch response were found for all samples.
The small muscle protein (smpx) is encoded by a recently discovered X-linked stretch response gene [ 16].
We propose that miRNAs may regulate some of the stretch response, and therefore hypothesized that miRNAs would be differentially expressed between cyclically stretched and unstretched rat alveolar epithelial cells (RAECs).
In the present report we suggest that the important stretch response of collagen made possible by collagen crimping is altered by morphologic changes in disc architecture during aging and degeneration.
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Medium-latency stretch responses of lower limb muscles in humans are thought to be transmitted to the spinal cord by secondary spindle afferents and relayed through an oligosynaptic spinal pathway [60], [61], [62], [63].
A number of studies over the last decade have indicated that NADPH oxidases are the main source of ROS involved in myocardial redox signaling and stretch responses [24,25].
For denser adsorbed layers, such experiments may not reflect the correct stretching response.
Comparison with the nano-handling technique reveals that the stretching response of individual molecules can be obtained with the pulling technique, provided the adsorbed polymer layer is dilute.
Here we investigate the stretching response of chromatin fibers by mesoscale modeling to complement single-molecule experiments, and present various unfolding mechanisms for fibers with different nucleosome repeat lengths (NRLs) with/without LH that are fixed to their cores or bind/unbind dynamically with different affinities.
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