Indeed, TrSA (but not TcTS) was found to cleave O and S-linked sialylated substrates, further stressing the functional differences between trypanosomal sialidases and trans-sialidases.
Deletion of genes encoding mitochondrial proteins leads to a reduction in peroxisome numbers, e.g., Cox6, Cox9, and Cox10, which are involved in mitochondrial respiration, further stressing the functional and metabolic links between peroxisomes and mitochondria.
In their publication they stress the functional importance of citrate in mitochondrial function and also mention that citrate "also acts as an "energy gauge", a powerful sensor and regulator of cell energy production, adjusting both production and need" (page 115 in [81]).
"My Trip to New York" records single and attached homes in boroughs beyond Manhattan, while "Military Architecture" stresses the functional Minimalism of Quonset huts and the like.
To obtain the accurate transverse shear stresses, the functional suitable for beams can be obtained by using the three-field Hu-Washizu (HW) variational principle.
Our data significantly expand the current spectrum of pathogenic variants in PRPS1, confirming that they are associated with a continuum disease spectrum, thus stressing the importance of functional studies and detailed clinical investigations for genotype phenotype correlation.
Taken together, these findings suggest that the four PRPS1-related phenotypes are part of the same disease spectrum, thus stressing the importance of the functional characterization of pathogenic variants as well as the interpretation of genotype/phenotype correlations.
A regression analysis of individual lesion overlap with either the ventral or dorsal fibre systems and individual comprehension or repetition impairment further stressed the specific functional contribution of both pathways (Fig. 4E and F).
Similarly, we showed by direct RNA transfection of a dicistronic transcript that the predicted IRES in the SPG4 exon 1 is not functional, further confirming the imprecision of bioinformatic approaches to predict IRES sequences and stressing the importance of adequate functional validation.
Most of these examples comprise genes critically involved in developmental processes, such as intercellular communication, intracellular signalling, or activation of cell-type specific gene expression, which is reminiscent of previous results stressing the over-representation of such functional categories in post-duplication retained genes [ 10].
We need to stress that the functional form of this model allows identification even without exclusion restrictions, although exclusion restrictions could always facilitate the estimation procedure, particularly in applications where there is not a lot of variation in the dependent variable.
