In their publication they stress the functional importance of citrate in mitochondrial function and also mention that citrate "also acts as an "energy gauge", a powerful sensor and regulator of cell energy production, adjusting both production and need" (page 115 in [81]).
Indeed, TrSA (but not TcTS) was found to cleave O and S-linked sialylated substrates, further stressing the functional differences between trypanosomal sialidases and trans-sialidases.
Deletion of genes encoding mitochondrial proteins leads to a reduction in peroxisome numbers, e.g., Cox6, Cox9, and Cox10, which are involved in mitochondrial respiration, further stressing the functional and metabolic links between peroxisomes and mitochondria.
Further, the study stresses the utility of functional contracting in pre-contractual integration.
This stresses the importance of functional metagenomics studies, where libraries of natural DNA are screened for specific enzymatic activities.
A regression analysis of individual lesion overlap with either the ventral or dorsal fibre systems and individual comprehension or repetition impairment further stressed the specific functional contribution of both pathways (Fig. 4E and F).
The surprisingly fast deterioration in IADL compared with cognitive and global performance stresses the clinical importance of functional evaluations during the early stages of dementia.
The term bilateral CP, suggested by the SCPE group, joins together spastic diplegia and tetraplegia, which further stresses the need for additional functional grading in order to correctly evaluate each child.
We need to stress that the functional form of this model allows identification even without exclusion restrictions, although exclusion restrictions could always facilitate the estimation procedure, particularly in applications where there is not a lot of variation in the dependent variable.
