These are complex effects, but the modelling does suggest that while "stress" inputs may reduce over time hormone negative feedback is a major factor reducing hormone responses.
The need to consider the effects of uncertainties in loading information, calculation of stresses, input data and material properties is emphasised.
How are UV and drought stress inputs combined?
In addition, it was a priori unlikely that every possible combination of different abiotic and biotic stress inputs had a separate sensor circuit reserved only for that combination.
For our analysis of factorial environmental inputs in these two maize mapping populations, we defined three simple logical expectations for the genetic architecture of combined stress inputs using the Trevino Santa Cruz et al. (2005) formulation for our expected maize stress effects.
We analysed simulated time course data of RsbR and RsbS phosphorylation, as well as steady state phosphorylations at different stress inputs and compared them to data from the literature.
More importantly, sestrins appear to function as a negative feedback regulator of mTOR that integrates metabolic and stress inputs and prevents gero-pathologies caused by chronic activation of mTOR.
In summary, we have demonstrated that the gene structure and cis-acting regulatory elements of WRKY53 are highly conserved between wheat and rice, and report several novel genes that act as either upstream regulators affording WRKY53 responsiveness to various biotic and abiotic stress inputs, or downstream targets involved in oxidative responses to stress.
Ageing is related to elapsed time (with different effects in different environmental conditions); damage is related to microstructural modifications due stress and/or strain inputs.
Stress, input stiffness, fatigue reliability, and force transmission are also the main constraints.
Open image in new window Fig. 11 Comparison between predicted and measured shrinkage stress (input parameters and measured shrinkage stress are extracted from Lange et al. (2003)).
