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We used DEM as a stress inducer, which clearly induced the formation of cytoplasmic inclusions and P-S349 signal.
ER stress inducer, Brefeldin A, and serum starvation, also induce oxidized MPYS formation (Figure S2a, S2b).
Microarray analysis revealed that CRELD2 and ALG12 mRNAs were induced in Neuro2a cells by treatment with thapsigargin (Tg), an ER stress inducer, in a time-dependent manner.
That's a stress inducer.
HeartMath, a creator of science-based solutions to reduce stress, recently turned to a stress inducer, technology, to create a tool to help users achieve serenity.
In the in vitro study, murine bEnd.3 cells were stimulated with phenazine methosulfate (PMS), an oxidative stress inducer.
WT and ALDH2 transgenic mice were subjected to the ER stress inducer thapsigargin (1 mg/kg, i.p., 48 h).
A slower process then took over, potentially indicative of cellular adaptation to the stress inducer, and generated a relatively low ISR over the next 21 hours.
These results are similar to those observed in COCs treated with the classical ER stress inducer thapsigargin (Wu et al., 2012).
Similar(2)
To corroborate these results with a different ER-stress inducer, similar experiments were performed in which cells were incubated with different concentration of thapsigargin (0 3 µM) [25].
The ER-stress inducer tunicamycin (1 μg/ml for 24 h) served as a positive control.
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