By utilizing QSP approaches, clinicians may develop a platform for improved dose individualization for subpopulation of BC patients, strengthen rationale in treatment designs, and explore mechanism elucidation for improving future treatments in BC medicine.
The previous study on the genetics of podoconiosis has also strengthened the rationale for providing shoes for unaffected children of affected families [ 12].
This not only strengthened the rationale for defining the three stages of tumor progression, but also suggested that PCT development is a continuous process during which tumor cells gradually increase metabolic activity while accumulating in lymphoid tissues.
Striking similarities between zebrafish and human tumors at the histological and molecular level has strengthened the rationale of using zebrafish as a laboratory cancer model over the past few years (Amatruda and Patton, 2008; Lam et al., 2006; Langenau et al., 2007; Nguyen et al., 2011).
Moreover, the different mechanisms of action of the two drugs, which have been shown to synergise in in vitro and in vivo models (Chow et al, 2000; Gallo et al, 2006), as well as the non-overlapping toxicity profiles, further strengthened the rationale for their combination.
In a sense, each criticism only strengthens the rationale for Gingrich to remain by weakening the rationale for him to drop out — what, exactly, would he gain?
Our data thus strengthen the rationale for the development of IMiDs, which have been shown to trigger loss of IRF4 expression in PEL34, as a treatment strategy.
Moreover, given how important his intent is to establishing a possible crime, Trump only strengthens the rationale for Mueller's interview.
"One of our reasons for doing this is to get an underpinning in neuroscience to strengthen the rationale for doing more studies, more trials on patients, and we are trying to gear up to do that in the next year.
Furthermore, prior knowledge about the clinical significance of such weight loss in improving quality of life and reducing cardiovascular outcomes would strengthen the rationale for weight loss in high-risk groups.
The results of this study enhance our understanding of the ability of aligned electrospun nanofibers to provide contact guidance to neural cells and strengthen the rationale for future in vivo studies.
