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This will have three major implications: (i) to design novel intervention studies that aim to strengthen protective factors and cognitive reserve, (ii) to provide an in vivo test system for the mode of action of potentially protective interventions, and (iii) to serve as a secondary endpoint for the effectiveness of interventions.
Optimization of PEGylation chemistries and/or densities on adenovirus-based vaccine that promote and strengthen protective immune responses following oral immunization is currently underway.
Adding recombinant IL-12 to lysates or RNA loaded DCs also can strengthen protective immunity against intracranial gliomas [ 95] and combining DC vaccination with IFN- β gene therapy benefits survival [ 96].
In principle, lower levels of leisure time sitting may strengthen protective effects of higher physical activity, either through independent physiological mechanisms [ 6] or as a marker for greater engagement in low-intensity activity, such as standing [ 34].
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In addition, UNICEF provides support to child protection including the protection of girls from violence, exploitation, abuse and discrimination by strengthening protective systems, supporting strategies and mechanisms for implementation of programmes.
These characteristics emphasize the importance of providing factual information and specifically addressing risky behaviors and strengthening protective factors.
The crisis-related programmes focus on strengthening the resilience of populations through promotion of appropriate coping mechanisms and strengthening protective factors for 'at risk' groups.
The lens of strengthening protective environments for children and adolescents was used as an overall shared thematic approach for the evaluation.
Current strategies to tackle the high infection rates in chronic drug users focus primarily on remediating harm, although proactive approaches strengthening protective mechanisms might be more desirable.
Adolescents with no depressive symptoms or mental health complaints may have poor motivation to enrol in a mental health promotion program, but a positive framing of the intervention and focus on strengthening protective factors could enhance interest.
Improving adolescent health requires improving the factors that make up young people's daily lives by addressing the risks and perhaps more importantly strengthening protective factors and resilience [ 33].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com