Another strength of our validation study was the thorough evaluation of medical records, which allowed for validation of key variables in the DKRR and made the DKRR a valid tool for future research.
Based on the strength of these validation studies, we considered that this combined methodology was suitable for investigating Helicobacteraceae prevalence in UC colonic biopsies.
A particular strength of our validation is the use of both captive and free-ranging macaques to demonstrate that relationships seen in captive animals can also be extrapolated into field settings, where animals usually have lower BMI and consequently also lower UCP levels.
In addition, the European Medicines Agency (EMA) in its reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products [9] states that it will evaluate the strength of evidence of validation including cultural adaptation/translation as applicable to the study.
Strengths of this validation study include the extensive review of medical records with very detailed data on prognostic factors, treatment, and outcome.
Finally, after some equations were proposed to calculate the parameters by using concrete compressive strength, the validation of these equations were also proved in this study.
The first strength of the study is validation through independent and blinded assessment by multiple observers over an extended period of time, in that several different nurses rated the same patients every time they came to pick up medications.
Although some have argued that a lack of predictive power for non-canonical seed sites casts doubt upon the biological validity of such interactions 42, this seems like a bold call considering the strength of the accompanying biological validation, and that our understanding of how RISC occupancy correlates with the strength of an interaction is far from complete 25.
With these consistent words and actions, I now feel a priceless sense of validation, freedom, and strength.
For an accurate validation, the strength of our study is the use of two objective measures to validate the questionnaires.
