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Our findings of heterogeneous structural alteration at the microscopic scale in edematous corneas suggest that the strength of collagen cross-linking is heterogeneous in the corneal stroma.
Lower panel shows the pixel-wise fiber directional analysis, enabled quantification of the local strength of collagen fiber alignment, which demonstrated reduced variance in fibers up to three weeks after PEF, but no significant difference in the directional variation within the PEF treated area two months after the treatment.
A small percentage of these hydroxylysine residues are precursors for the cross-link formation essential for the tensile strength of collagen.
The hydroxylation of proline is an important contributor to the strength of collagen, as it forms hydrogen bonds and water bridges, which stabilize the triple helix (35, 36).
These covalent cross-links prevent collagen molecules from sliding past one another and are the basis of the tensile strength of collagen fibre systems.
Finally, remodeling is a slow dynamic process, in which cell density and vascularization are diminished, while the total amount and the tensile strength of collagen increase (Jeffcoate et al 2004; Falanga 2005).
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Orientational anisotropy of collagen molecules is integral to the mechanical strength of collagen-rich tissues.
The physical and tensile strength of collagens are typified by collagen type I (having the tensile strength of steel), which predominates in bones, tendons, skin, and mature scars, while type II collagen is thinner and predominates in cartilage, vitreous humor and nucleus pulposus.
Bone collagen content and mechanical strength of the collagen matrix increases until three months of age in rabbits, when it attains maturity and prior to overall skeletal maturity at around 6 months [52,53].
The electrospun fibrous PLGA layer on the surface of a porous tubular collagen scaffold improved the mechanical strength of the collagen scaffolds in both the dry and wet states.
The results showed that the changes in the collagen anisotropy measured in experiments were insufficient to explain the increase in the stiffness and strength of the collagen constructs with cyclic loading and that the increase in the strength of the collagen constructs may be attributed mainly to the increase in the effective stiffness of the fibrils.
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advantage of collagen
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degree of collagen
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