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RhoA activity correlated inversely with the strength of cell adhesion to the substrates.
The strength of cell adhesion onto gels was assessed via a centrifugation assay.
It has been found previously that the increase in the disorder strength of cell nanoarchitecture is one of the earliest events in carcinogenesis.
Since the cell wall is the first line of defense against external stresses, the strength of cell wall and the effective cell wall remodeling may be essential for tolerance to various environmental stresses.
The initial cell attachment behavior, especially the strength of cell adhesion to the material surface, was evaluated quantitatively by determining the slope of the Df plots using the QCM-D system.
As expected, the strength of cell orientation toward the gradient (i.e. ΔLR*) decreases with increasing kdes, and the specific dependence of cell orientation on kdes varies with the cell position in the gradient field (Figure 2C).
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Despite of the progress made to engineer structured microtissues such as BioMEMS and 3D bioprinting, little control exists how microtissues transform as they mature, as the misbalance between cell-generated forces and the strength of cell-cell and cell-substrate contacts can result in unintended tissue deformations and ruptures.
Meprinβ-expressing cells displayed a reduced strength of cell-cell contacts and a significantly lower tendency to form multicellular aggregates.
While the significance of the number of ectodomains is less well understood, the relative strength of cell-cell adhesion may be affected [2].
It has been suggested that incorporation of α-SMA into stress fibers directly correlates with the strength of cell-matrix adhesion and is crucial for cell contractility and cell spreading [41].
The energy curves in the OT and COT structures indicated that the tensile actin filaments contribute to the major strength of cells, while the compressive microtubules stabilize the cell structure (Figs. 2D and 5).
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