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The retrograde signals in flies are crucial for regulating local synaptic strength during development (Keshishian and Kim, 2004), homeostasis (Goold and Davis, 2007), and synaptic plasticity (Tao and Poo, 2001).
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8 Failure to acquire optimal bone mass and strength during growth and or an unbalance in bone remodeling leading to bone loss throughout life may all contribute to the development of the disease.
miR-181a also regulates T-cell-receptor sensitivity and signal strength during T-cell development, in part by targeting tyrosine phosphatases [ 37].
It is not clear as to how the RA metabolic enzymes coordinate with each other to generate the RA gradient at right time, right region, and with right strength during early embryonic development.
It seems that the relative strength of expression changes during development.
Whether the resultant change in phenotype from this latter group is adaptive (i.e., might confer a fitness advantage) depends on the nature and strength of the stimuli during development and whether they convey useful information about the external environment later in life.
In separate work Bedont et al. also identified Lhx1 as a critical transcription factor that helps set up the strength of the SCN network during development (Bedont et al., 2014).
Bone measurements by the pQCT technique provide information on bone acquisition, architecture, and strength during rapid periods of growth and development.
Below we draw this contrast and show that our results on how the number and strength of HVC input to RA changes during development could not have been inferred from prior studies.
This has a strong influence on the microstructural and mechanical strength development during setting and hardening.
This model considers the development of shear strength during soil consolidation and loading unloading scenarios at the pile soil interface.
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