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Infectious disease consultants and supervisors streamlined therapy based on gram-stain results only.
In addition, quality-life-indicators should theoretically have the capacity to detect any favorable impact of streamlined therapy upon perceptions of the disease state.
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Currently, the use of combination inhalers (beta-agonist/corticosteroid) is recommended as a means to streamline therapy in patients with persistent asthma.
Residents were hesitant to streamline initial therapy, fearing that such changed therapy might be clinically less effective.
The procedure resulted in the selection of a final set of five QIs, namely: obtain cultures; prescribe empirical antimicrobial therapy according to the national guideline; start intravenous drug therapy; start antimicrobial treatment within one hour; and streamline antimicrobial therapy.
In contrast to their statements supporting streamlining antimicrobial therapy, residents reported that they were not inclined to change therapy with an effective broad-spectrum antimicrobial agent, once the pathogens' sensitivity test results became available.
Three separate working groups have convened to publish evidence-based clinical guidelines to help streamline PN therapy during SCT.
The guideline recommends streamlining antimicrobial therapy to intravenous penicillin G or oral amoxicillin based on sensitivity-tests of the isolated S. pneumoniae.
In 5.1% of patients, streamlining of therapy, defined as de-escalation to narrower spectrum antibiotic in response to patient improvement or confirmed microbiological diagnosis, was undertaken; this was not counted as initial antibiotic treatment modification.
Thus, interventions aiming at improving antibiotic prescribing should focus on both initial empirical therapy and streamlining and adjustment of therapy.
Interventions aiming at improving antibiotic prescribing should focus on both initial empirical therapy and streamlining and adjustment of therapy once microbiological results become available.
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