But Eaton says his team is already pursuing ideas to streamline the synthesis.
We are now in a position to establish a range of analytic filter-design rules to refine our search space and streamline Walsh synthesis leveraging approaches similar to electrical or digital signal filter construction.
To streamline controller synthesis, two output filters were introduced (inverting the Hill dose response model and the linear time-invariant sensor model), which yield a close-to-linear representation of the system dynamics when used with a compartmental patient model.
This streamlines the synthesis and increases the efficiency considerably, because pre-functionalization (often achieved within multi-step sequences) of substrate(s) is no longer required.
To facilitate this process, an innocuous Gly76Ala mutation was introduced at the C-terminus of ubiquitin to streamline the synthesis of an H2B-K120ub analogue.
As this review illustrates, more and more stereogenic structural motifs have become accessibile through transition-metal-catalyzed cross-coupling, allowing chemists to leverage the flexibility of cross-coupling to streamline the synthesis of complex molecules.
In an effort to further streamline the synthesis process, a new automated platform including a new linker, a new custom-made synthesizer, and an improved chemical strategy was recently published (Fig. 4).
