As the analyses became more complex and incorporated an increasing number of modules, several tools and frameworks appeared that aimed to streamline computations and automate workflows.
Tools and frameworks aiming to streamline computations and automate standard analysis bioinformatics workflows include Galaxy [17], Bioconductor [16], EMBOSS [39] and Bioperl [43].
In this architecture, the large availability of memory is heavily exploited to streamline the computation, avoiding disk access whenever possible, allowing an extremely faster sequential processing and caching of the intermediate results.
Two procedures were implemented to streamline these computations.
To streamline these computations of coverage for the percentile method, data is restricted to the Hiroshima subcohort (N = 1536 cells) and the model simplified to use 10-year rather than 5-year age-at-exposure categories.
Since the method computes streamline coordinates directly, it can be easily used to generate boundary fitted grids for the computation of three-dimensional viscous flows.
Additionally, the LAMP structure (Ubuntu, version 8.04; Apache, version 2.04; Postgresql, version 8.3.7; PHP, version 5.1.0) and a MS-Window 2003 server are adopted to take the computation load and streamline the workflow control (PalmDaemon).
The proposed approach combines aspects of the existing approaches, but is simpler, requires fewer assumptions and streamlines the computation.
Finally, an examination of the scaling behavior of the computation time indicates that the streamline approach is likely to result in significant savings for large-scale field applications.
Key aspects of streamline simulation are the accurate tracing of streamlines and the computation of travel time along individual streamlines.
