Sentence examples for stream regulator from inspiring English sources

However, despite of down regulation of the down stream regulator of calcineurin signaling encoding gene CRZ1, it did not appear to have any significant role in iron mediated stress responses as the phenotypic consequences in Δcrz1 mutant differs from that of calcineurin and conditional HSP90 mutants (Fig. 3C).

In many cases gene activities are correlated, e.g., due to a common upper stream regulator.

Expression levels of up stream regulators of C4BPB such as HNF-3 and PFKFB2 [ 40, 41] were suppressed, which may explain the decreased expression of C4BPB we observed in the bovine liver during the APR.

Our data are consistent with the possibility that Dsg3, as an up-stream regulator of Src activity, helps regulate adherens junction formation.

In conclusion, we propose that the high risk of mortality from CRC related causes in patients who exhibit A-type lamin expression within their tumour arises because lamin A is an up-stream regulator of a pathway linking actin dynamics to loss of cell adhesion, thus leading to increased cell motility and consequently increased invasive potential of the tumour.

HSF1 is another up-stream regulator of survivin.

A recent study proposes that the up-stream regulator of Bcl11b is TCF-1 which is activated by Notch1 signals [ 76].

Although its up-stream regulator(s) remained unknown, the role of TPH1 5-HT sysTPH1 5-HTucosystemeontasis has been well documented.

As a working model, we speculate that CgSoxH may play a leading role in the sex-determining pathway of C. gigas as it is closely related to the up-stream regulator Sry in vertebrates and strictly expressed in testis.

The homeobox gene MSX2, which is implicated in osteoprogenitor cell function [ 23] and an up-stream regulator of RUNX2, which was described to be important for the osteogenic differentiation [ 24], were up-regulated during the whole period of differentiation.

The significance of our findings was reinforced by the in silico identification of networks of DEGs and the prediction of the most significant upstream regulators for each network, including the prediction that ATF4 was an up-stream regulator of the ER stress pathway (Table  3).