A consensus panel was convened to review data and propose a strategy for trial design and prioritization.
We aimed to determine whether a prospective TB is an effective strategy for trial recruitment and to identify steps within the TB process that facilitate discussion of trial eligibility and optimize accrual.
Section 'A strategy for design and analysis of clinical trials discusses our proposed strategy for trial design and analysis.
This finding is in accord with the few prior trials of recruitment-enhancing strategies for trials with cancer patients [ 6, 15].
Indeed, clinical testing of an antimetastatic approach to cancer may require new strategies for trials so that the occurrence of cancer metastases can be monitored.
It discusses the principles of site discovery by means of trial trenching, and suggests the optimal strategies for trial trenching survey, based on the results of simulations.
The goal, says Barsan, is to use an existing neurological trials network as a laboratory to examine this strategy for improving trials.
Characterization of these pharmacodynamic properties for a new drug in development can help direct the design of the best dose and dosing strategy for clinical trials.
This finding suggests a new strategy for future trials in the ICU: utilizing tissue oxygenation/microcirculatory parameters to determine the need for transfusion rather than largely arbitrary hemoglobin concentrations.
Such work is often conducted in the early planning stages of a clinical outcomes assessment strategy for clinical trials, where a broad understanding of salient disease-related concepts is first sought before selecting those of most interest to target through subjective assessment.
