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Magnetic targeting, a promising therapeutic strategy for localizing systemically delivered drug to target tissue, is limited by magnetic attenuation.
To this end, this work explores collagen anchoring of immunotherapeutic agents to the tumor extracellular matrix as a potential strategy for localizing their immunomodulatory effects to the tumor.
These findings highlight an innovative strategy for localizing pre-malignant lesions within the epithelium based on suspected alterations in protein expression rather than on gross architectural abnormalities, and the results suggest that the approach may have potential to enhance the diagnostic specificity of endoscopy in the clinical setting.
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Active surveillance (AS) has gained acceptance as a management strategy for localized renal masses.
Thermosensitive liposomes have emerged as a viable strategy for localized delivery and triggered release of chemotherapy.
Strawberry confections may be a novel strategy for localized delivery and sustained release of strawberry bioactive compounds.
According to previous reports, surgical treatment with regional lymph node dissection may be a treatment strategy for localized esophageal MANEC.
Sarver is more optimistic about Dowdy's idea to adapt the strategy for localized cancer treatment, by using a TAT/caspase that can only be activated by tumor cells.
While this might be a motor strategy for localized tasks such as upper cervical flexion, our findings reveal that altered motor patterns are not generalizable to activities of the lower limb, indicating that there is no tendency towards increased neck muscle tension in situations that do not require neck muscle strength.
A different but equally effective strategy for localized biochemistry involves the formation of phase-separated macromolecular assemblies, which are built de novo from proteins and RNAs (Brangwynne, 2011; Hyman and Simons, 2012; O'Connell et al., 2012; Wilson and Gitai, 2013).
Our results demonstrate that the auditory system can indeed switch between different strategies for localizing sound depending on the sensory context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com