To provide an overview of the functional significance of prioritized genes from seed- and DE-based network strategies, we grouped the top-ranked genes into 2-strategy winners (genes identified by both seed-based and DE-based strategy), DE-only winners (genes specifically identified by deHKDR method), and seed-only winners (genes specifically identified by seed-based strategy, either sHKDR or RWR).
Top-ranked genes specifically identified by the DE-based strategy (DE-only) or the seed-based strategy (seed-only) or the winners prioritized by both strategies (2-strategy) were grouped into three winner sets and mapped to the genes supported by genetic evidence and functional evidence or both.
Despite the existence of such predefined strategies, de-escalation rate may probably be largely improved.
To further understand the difference between the two strategies, DE-based and DCE-based, we compared the DDLs identified by the two methods and found that only 162 disease links (~12 %, as shown in Fig. 1) were common.
With the company's shift in business strategy, using the moral high ground for a dollars-and-cents strategy, De Beers, by its own account, may well be starting to turn a corner.
"I'm sorry it has taken you so long to respond, but I guess Mr. Giuliani's falling poll numbers necessitated a change in your strategy," Mr. de Blasio said.
This work shows a strategy of de novo production of lovastatin from methanol in the methylotrophic yeast P. pastoris as a host.
"It's because they all share the same hunting strategy," says de Winter, "and so natural selection has shaped their brains in the same way.
The present study highlights the importance of protein engineering as a key strategy in de novo pathway design and overproduction of desired products.
Without a proposed strategy for de novo sequencing using these technologies, their future potential may be restricted to re-sequencing for mammalian genomes.
