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This is supported by Gamma+ plots, showing that while assemblages tended to cluster by region (Supplementary Fig. S2A), they did not form groups by depths strata (Supplementary Fig. S2B).
Analysis stratified by thirds of the propensity score showed that the hazard ratios for stroke were similar in the three strata (supplementary table B).
Although there was a trend toward higher CVD risk with higher fetuin-A levels, this association was not statistically significant among the diabetic strata (Supplementary Data).
We then regrouped these trajectories into five levels based on patterns of ISI 0,120) (6) at follow-up across nine strata (Supplementary Table 1).
To explore whether associations between smoking status and risk might be due to confounding by alcohol consumption, we estimated associations within strata of alcohol consumption and found that the association remained elevated across strata (Supplementary Table 2).
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The evolution of disease activity outcomes was analysed using generalised mixed models for longitudinal data, adjusting for potential confounding factors using the propensity score stratas and the potential effect modifiers (supplementary appendix).
The risks in the combined strata using myopia versus emmetropia as the outcome showed similar trends, however, ORs were lower in all strata and the synergy index did not reach statistical significance (Supplementary Table 1, Supplementary Figure 2).
The Supplementary Material contains estimated PPVs across strata defined by combinations of variables and for a long baseline period of 12 months.
Similar to the expectations, when analyzing just the coding regions, the segmentation and clustering algorithm produces a conservative strata structure (fig. 1 and supplementaryfig. S2, Supplementary Material online).
The strata separation appears in the overburden strata of roof.
The strata sample sizes were determined as detailed in the online supplementary file.
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